The primary aim of this project is to understand what happens to C. neoformans after it is ingested by phagocytic cells. Macrophages are our first line of defense after cryptococcal infection but the ability of Cryptococcus to manipulate macrophages and avoid destruction is a major factor in its pathogenicity in the immunocompromised.

We areĀ using the amoeba Dictyosteliumdiscoideum to investigate what happens to Cryptococcus within a model phagocytic cell. We are using Dictyostelium because there are a large number of resources available for studying phagocytosis and phagosomes and because it gives the opportunity to investigate the environmental interactions of Cryptococcus that have driven the evolution of virulence to human macrophages.

Join the Lab

We always welcome enquiries if you are interested in joining the lab. To find out more, click here.