A major risk factor for cryptococcal infection is immunosuppressive therapy, for example after solid organ transplantation or for autoimmune disease. There are a wide variety of drugs used for immunosuppressive therapy with very different mechanisms of action.  

In this project we are investigating specific defects that these drugs may cause, either directly or indirectly, in macrophages that increase susceptibility to infection. Our aim is that the macrophage phenotype may be modified to increase anti-infective behaviour while maintaining the required primary immunosuppressive profile. 

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